N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
AssigneeEli Lilly and Company
InventorRichard Pioch
Life of this patent
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Abstract
N-alkyl-N'-(2-aminomethyl-4-thiazolylmethylthio)alkyl guanidines, thioureas, ethenediamines and related compounds, H.sub.2 -receptor antagonists, useful in inhibiting gastric acid secretion in mammals.
Claims9
A compound of the formula ##STR35## wherein R.sup.1 is methyl, ethyl, H, benzyl or benzoyl;
- R.sup.2 is methyl or ethyl;
- or when taken together with the nitrogen to which they are attached, R.sup.1 and R.sup.2 represent piperidino, pyrrolidino or morpholino;
- R.sup.3 is H or methyl;
- and
- X is OH, SH or a group labile to nucleophilic displacement.
A compound of the formula ##STR36## wherein R.sup.1 is H, methyl, ethyl, benzyl or benzoyl, R.sup.2 is methyl or ethyl or R.sup.1 and R.sup.2 when taken together with the nitrogen to which they are attached, represent piperidino, pyrrolidino or morpholino;
- R.sup.3 is H or methyl;
- Z is O, S, or CH.sub.2 ;
- n is 2 or 3 when Z is O or S, and n is 1, 2 or 3 when Z is CH.sub.2 ;
- and acid addition salts thereof.
A compound of the formula ##STR37## wherein n is 2 or 3, and R.sup.1 is H, methyl, ethyl, benzyl or benzoyl;
- R.sup.2 is methyl or ethyl;
- or R.sup.1 and R.sup.2, when taken together with the nitrogen to which they are attached, are piperidino, pyrrolidino or morpholino.
Dependencies are inferred from the claim text.