Quinoline compounds as antiallergic and antiinflammatory agents
AssigneeAmerican Home Products Corporation
InventorsJohn H. Musser, Dennis M. Kubrak, Anthony F. Kreft, III, Reinhold H. W. Bender
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AssigneeAmerican Home Products Corporation
InventorsJohn H. Musser, Dennis M. Kubrak, Anthony F. Kreft, III, Reinhold H. W. Bender
Estimating the term…
There are disclosed compounds of the formula ##STR1## wherein R.sup.1 is ##STR2## n is 0-5; R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo; R.sup.3 is hydrogen or loweralkyl; R.sup.4 hydrogen, lower alkyl, --COOR.sup.3 or ##STR3## R.sup.5 is lower alkyl, monofluoroloweralkyl, difluoroloweralkyl, polyfluoroloweralkyl, perfluoroloweralkyl or ##STR4## and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, and as antiinflammatory agents.
A compound having the formula ##STR36## wherein R.sup.1 is ##STR37## R.sup.2 is hydrogen, loweralkyl, loweralkoxy, lower alkoxycarbonyl, trifluoromethyl, nitro, cyano or halo;
Dependencies are inferred from the claim text.