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US 4,904,770 AGranted
Production of 2',3'-dideoxy-2',3'-didehydronucleosides
AssigneeBristol-Myers Company
InventorsJohn E. Starrett, Jr., Muzammil M. Mansuri, John C. Martin, Carl E. Fuller, Henry G. Howell
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Abstract
There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficiency viruses (HIV).
Claims1
A process for producing a 2',3'-dideoxy-2',3'-didehydronucleoside represented by the formula ##STR24## wherein B is a member selected from the group of bases consisting of uracil, and 5-methyluracil comprising the steps of:
- (a) reacting a starting ribonucleoside represented by the formula ##STR25## with an acyloxyisobutyryl bromide in a polar solvent under anhydrous conditions at an elevated temperature of about 75.degree.-100.degree. C. for about 1-3 hrs to obtain a reactive intermediate represented by the formulas ##STR26## wherein R represents the acyloxyisbutyryl group and R' represents the acyl group of the acyloxyisobutyryl bromide;
- (b) subjecting the intermediate from step (a) to an elimination reaction by treatment of said intermediate in an aprotic polar solvent with Zn/Cu reagent. ##STR27## (c) deprotecting the 5'--O-protecting group in the intermediate from step (b) by treatment of said intermediate with a mild base to give derived 2',3'-dideoxy-2',3'-didehydronucleoside.
Dependencies are inferred from the claim text.