Epipodophyllotoxin glucoside 4'-phosphate derivatives

A compound having the formula ##STR10## wherein R.sup.6 is H and R.sup.1 is selected from the group consistng of (C.sub.1-10)alkyl;

• (C.sub.2-10)alkenyl;
• (C.sub.5-6)cycloalkyl;
• 2-furyl;
• 2-thienyl;
• (C.sub.6-10)aryl;
• (C.sub.7-14)aralkyl;
• and (C.sub.8-14)aralkenyl wherein each of the aromatic rings may be unsubstituted or substituted with one or more groups selected from halo, (C.sub.1-8)alkyl, (C.sub.1-8)alkoxy, hydroxy, nitro, and amino;
• or R.sup.1 and R.sup.6 are each (C.sub.1-8)alkyl;
• or R.sup.1 and R.sup.6 and the carbon to which they are attached join to form a (C.sub.5-6)cycloalkyl group;
• X is oxygen or sulfur;
• R.sup.7 and R.sup.8 are independently selected from the group consisting of H, (C.sub.1-5)alkyl, halo-substituted (C.sub.1-5)alkyl, cyano-substituted (C.sub.1-5)alkyl, (C.sub.3-6)cycloalkyl, (C.sub.6-10)aryl, (C.sub.7-14)aralkyl, wherein the ring portion of said aryl and aralkyl groups is unsubstituted or substituted with a group selected from the group consisting of alkyl, halo, and nitro;
• or a pharmaceutically acceptable salt thereof.