Nifedipine concentrate stabilized against the influence of light and a process for its preparation
OwnerKurt H. Bauerinventor
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Abstract
A nifedipine concentrate stabilized against the influence of light is described, characterized in that it contains nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B.sub.2, based on the nifedipine, at least one surface-active agent and optionally conventional carriers. A process for the preparation of the nifedipine concentrate and a medicament containing nifedipine and its use for the production of pharmaceutical preparations are also described.
Claims16
Nifedipine concentrate stabilized against the influence of light, comprising nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B.sub.2, based on the nifedipine, and at least one surface-active agent.
A process for the preparation of a nifedipine concentrate stabilized against the influence of light, comprising:
- (a) dissolving nifedipine and polyethylene glycol in an organic solvent to form a solution,
- (b) adding to the solution of (a) an aqueous solution or suspension of Vitamin B.sub.2, at least one of the solution of (a) or said aqueous solution or suspension of Vitamin B.sub.2 also containing surface-active agent,
- (c) mixing the result of (b),
- (d) concentrating by evaporation the result of (c) to isolate a stabilized product.
Medicament comprising nifedipine, polyethylene glycol, from 0.5 to 20% by weight of Vitamin B.sub.2, based on the nifedipine, at least one surface-active agent and pharmaceutical carriers.
Dependencies are inferred from the claim text.