Organic compounds and their use as pharmaceuticals
AssigneeLilly Industries Limited
InventorsMaria I. F. Fernandez, Terrence M. Hotten, David E. Tupper
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AssigneeLilly Industries Limited
InventorsMaria I. F. Fernandez, Terrence M. Hotten, David E. Tupper
Estimating the term…
Compounds of the following formula have pharmacutical properties: ##STR1## in which R.sup.1 and R.sup.2 independently are hydrogen, halo, nitro, amino, C.sub.2-5 acylamino, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R.sup.1 and R.sup.2 together form a C.sub.3-5 alkylene bridge, R.sup.3 is C.sub.1-4 alkyl or C.sub.2-4 alkenyl, and X is (i) --(CH.sub.2).sub.n N(R.sup.4).sub.2 where each R.sup.4 independently is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or optionally substituted C.sub.6 H.sub.5 CH.sub.2 --, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C.sub.1-3 alkylene chain; and salts thereof.
A compound of the formula ##STR12## in which R.sup.1 and R.sup.2 independently are hydrogen, halo, nitro, amino, C.sub.2-5 acylamino, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, imidazolyl attached through a nitrogen atom, pyrazolyl attached through a nitrogen atom, attached through a nitrogen atom, phenyl, phenylthio, phenylsulphonyl or phenylsulphonamido, or phenyl, phenylthio, phenylsulphonyl or phenylsulfonamido substituted with one to three halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, nitro, cyano, amino, carboxy or carboxamido groups, or R.sup.1 and R.sup.2 together form a C.sub.3-5 alkylene bridge, R.sup.3 is C.sub.1-4 alkyl or C.sub.2-4 alkenyl, and X is (i) --(CH.sub.2).sub.n N(R.sup.4).sub.2 where each R.sup.4 independently is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.6 H.sub.5 CH.sub.2 --, or C.sub.6 H.sub.5 CH.sub.2 -- substituted with one to three halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, nitro, cyano, amino, carboxy or carboxamido groups, and n is 1, 2 or 3, or (ii) an alicyclic group which is ##STR13## m is 1, 2 or 3 and R.sup.5 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl or benzyl substituted with one to three halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, nitro, cyano, amino, carboxy or carboxamido groups;
4,5-Dimethyl-N -[(1-ethyl-2-pyrrolidinyl)methyl]-3-methoxythiophene-2-carboxamide or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.