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US 4,904,685 AGranted
Antiallergy and antiinflammatory agents
AssigneePfizer Inc.
InventorsYoshihiko Kitaura, Fumitaka Ito, Rodney W. Stevens, Nobuko Asai
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as antiallergy and antiinflammatory agents.
Claims6
A compound of the formula ##STR53## or a pharmaceutically acceptable acid addition salt thereof, wherein R is hydrogen, alkyl having one to three carbon atoms, benzyl or carboxymethyl;
- R.sub.1 is acetoxy, thiophenoxy, hydrogen, fluoro, chloro, methoxy, methyl or trifluoromethyl;
- R.sub.2 is hydrogen, alkyl having one to three carbon atoms, alkanoyl having one to three carbon atoms or benzyl;
- X is CH.sub.2 ;
- n is an integer of 1 to 7;
- and Y is styryl, methyl, N-methylphenylamino, N-benzylphenylamino, phenylamino, phenoxy, thiophenoxy, thienyl, furyl, pyridyl, phenyl, substituted phenyl wherein said substituent is methyl, dimethylamino, methoxy, fluoro or chloro, or disubstituted phenyl wherein said substituents are each chloro, hydroxy or methoxy with the proviso that when Y is phenoxy, thiophenoxy, phenylamino, N-methylphenylamino or N-benzylphenylamino n is 2-7.
2 more elements
Dependencies are inferred from the claim text.