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US 4,904,674 AGranted
1-(Benzo[b]thienyl)-2-(thienyl)ethenes and related compounds useful as anti-inflammatory agents
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsLawrence L. Martin, Joseph F. Payack
Life of this patent
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Abstract
Novel 1-(benzo[b]thienyl)-2-(thienyl)ethenes, processes for the preparation thereof, and methods of reducing inflammation utilizing compounds and compositions there are disclosed.
Claims28
A compound of the formula
- wherein R.sup.1 and R.sup.2 are independently hydrogen or loweralkyl;
- X is hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl;
- Y is halogen, loweralkyl, hydroxymethyl, formyl, carboxy, loweralkoxycarbonyl, loweralkanoyloxymethyl, (N-loweralkyl-N-hydroxyamino)carbonyl, .omega.-haloloweralkyl, carboxyloweralkylidene, loweralkoxycarbonylloweralkylidene, (N-loweralkyl-N-hydroxyamino)loweralkyl, (N-cycloalkyl-N-hydroxyamino)carbonyl, (N-cycloalkyl-N-hydroxamino)loweralkyl, a group of the formula ##STR19## a group of the formula ##STR20## a group of the formula CO.sub.2 CH.sub.2 CH(OH)CH.sub.2 OH, a group of the formula CH(OH)CH(CO.sub.2 R.sup.3)NHCOR.sup.4 wherein R.sup.3 and R.sup.4 are loweralkyl, a group of the formula CH(OH)CH(CH.sub.2 OH)NHCOR.sup.4 where in R.sup.4 is loweralkyl, or a group of the formula CH(OH)CH(CH.sub.2 OH)NH.sub.2 ;
- a geometric or optical isomer thereof, or the pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.