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US 4,904,667 AGranted
1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method for increasing the cardiac output of a mammal with them
AssigneeOrtho Pharmaceutical Corporation
InventorsJames P. Demers, Richard B. Sulsky
Life of this patent
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Abstract
1H-1,2,4-thiadiazolo[3,4-b]quinazolin-5-one-2,2-dioxides are disclosed. These compounds are useful as caridotonic agents. A preferred compound is 7-(n-cyclohexyl-N-methyl-4-amino-4-oxobutyloxy)-1H-1,2,4-thiadiazolo[3,4-b ]quinazolin-5-one-2,2-dioxide.
Claims11
A 1H-1,2,4-thiadiazolo[3,4-b]quinazoline-5-one-2,2-dioxide of the Formula:
- ##STR1## wherein each R individually represents halogen, hydroxyl, lower alkyl, OR.sup.1, wherein R.sup.1 represents lower alkyl which may be substituted by R.sup.2 R.sup.3 N--CO-- wherein R.sup.2 and R.sup.3 individually represent lower alkyl or cycloalkyl, nitro, amino which may be substituted by R.sup.1 wherein R.sup.1 is as described above, or R.sup.1 S(O).sub.x wherein R.sup.1 is as described above and wherein x represents a number having a value of from 0 to 2, and wherein n represents a number having a value of from 0 to 4.
Dependencies are inferred from the claim text.