N-(2-oxpyrrolidin-1-yl-)acetyl)piperazine derivatives and drug for senile dementia
AssigneeShionogi & Co., Ltd.
InventorsHiromu Matsumura, Hiroshi Hashizume, Akira Matsushita, Masami Eigyo
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Abstract
A compound of the formula: ##STR1## (wherein R is --SO.sub.2 R.sup.1 or --CONHR.sup.2 ; R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.8 -C.sub.12 phenylalkenyl, amino, dimethylamino, optionally substituted C.sub.8 -C.sub.12 aryl, or 5- or 6-membered heterocyclic group including at least one hetero atom selected from the group consisting of N, S, and O; R.sup.2 is amino, C.sub.1 -C.sub.8 alkylamino, C.sub.1 -C.sub.8 alkyl, or optionally substituted C.sub.8 -C.sub.12 aryl) or its pharmaceutically acceptable acid-addition salt, being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.
Claims18
A compound of the formula ##STR28## wherein R is --SO.sub.2 R.sup.1 or --CONHR.sup.2 ;
- R.sup.1 is methyl, ethyl, isopropyl, n-butyl, dimethylamino, pyridyl, thienyl, phenylethenyl, or naphthyl;
- and R.sup.2 is methyl, n-butyl, fluorophenyl, metoxyphenyl, naphthyl or amino.
Dependencies are inferred from the claim text.