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US 4,904,658 AGranted
Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
AssigneeAmerican Cyanamid Company
InventorsShin S. Tseng, Joseph W. Epstein, Jeremy I. Levin
Life of this patent
Estimating the term…
Abstract
Substituted-6H,8H-pyrimido[1,2,3-cd]purine-8,10(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones which are useful as cognition enhancing agents, anxiolytic agents and/or antihypertensive agents in the treatment of cognitive and relative neutral behavioral problems, anxiety and hypertension in mammals.
Claims17
Compounds of the formulae:
- ##STR10## wherein the structure ##STR11## may be ##STR12## R.sub.1 is hydrogen, alkyl(C.sub.1 -C.sub.6), carbamylmethyl, benzyl or p-nitrobenzyl;
- R.sub.2 is 3-pyridinyl or a moiety of the formula:
- ##STR13## wherein R.sub.3 and R.sub.4 are each individually selected from the group consisting of hydrogen, halogen, alkyl(C.sub.1 -C.sub.3), nitro, alkoxy(C.sub.1 -C.sub.3), 4-morpholinyl and trifluoromethyl;
- and R.sub.5 is alkyl(C.sub.1 -C.sub.3).
1 more element
Dependencies are inferred from the claim text.