Thieno[2,3-O]azepine compounds and CNS affecting use thereof
AssigneeLilly Industries Limited
InventorsBarry P. Clark, David E. Tupper
Life of this patent
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AssigneeLilly Industries Limited
InventorsBarry P. Clark, David E. Tupper
Estimating the term…
Compounds of the formula ##STR1## in which R.sup.1 is hydrogen, hydroxy, nitro, cyano, halo, amino, acetamido, hydroxy-C.sub.1-4 alkyl, carboxaldehydo, C.sub.1-4 alkylcarbonyl, carboxy, C.sub.1-4 alkoxy-carbonyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl or C.sub.1-4 alkoxy-C.sub.1-4 alkyl, R.sup.2 is hydrogen, hydroxy, nitro, cyano, halo, amino, carboxamido, acetamido, hydroxy-C.sub.1-4 alkyl, carboxyaldehydo, C.sub.1-4 alkylcarbonyl, carboxy, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, oximino or aminomethyl, R.sup.3 is optionally substituted phenyl or optionally substituted phenyl ortho condensed with an optionally substituted ring selected from benzene, cyclohexane, cyclohexene, cyclopentane or cyclopentene, in which ring one of the carbon atoms may be replaced by oxygen, sulphur or nitrogen, and R.sup.4 is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or optionally substituted benzyl; and salts thereof; have central nervous system activity.
A compound of the formula ##STR10## in which:
A compound of formula ##STR11## in which R.sup.1 is halogen or C.sub.1-4 alkylthio, R.sup.2 is hydrogen, hydroxy-C.sub.1-4 alkyl, C.sub.1-4 alkyl or halo, R.sup.3 is phenyl or benzofuranyl, and R.sup.4 is hydrogen or C.sub.1-4 alkyl, or a salt thereof.
A compound of formula ##STR12## in which R.sup.1 is hydrogen, halo or C.sub.1-4 alkylthio, R.sup.2 is hydrogen, hydroxymethyl, halo or C.sub.1-4 alkyl, R.sup.3 is phenyl or benzofuranyl and R.sup.4 is hydrogen or C.sub.1-4 alkyl, or a salt thereof.
Dependencies are inferred from the claim text.