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US 4,904,651 AGranted
Anxiolytic 4-aminoquinoline-3-carboxamides
AssigneeICI Americas Inc.
InventorEdward J. Warawa
Life of this patent
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Abstract
The present invention comprises certain amide derivatives of 4,8-disubstituted quinoline-3-carboxylic acids of formula I; pharmaceutically acceptable salts of the compounds of formula I; pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment of anxiety; and processes for the manufacture of the compounds of formula I, as well as intermediates for use in such manufacture.
Claims8
A compound of formula I
- wherein
- Ra is selected from the group consisting of (1-10C)alkyl, (3-10C)cycloalkyl, (4-10C)cycloalkylalkyl, (2-10C)alkenyl, (2-10C)alkynyl, (6-10C)aryl, (7-12C)arylalkyl, (1-10C)haloalkyl having one to five halo group(s) wherein the halo group(s) is selected from chloro and fluoro, (2-10C)hydroxyalkyl, (4-10C)hydroxycycloalkylalkyl, and thienyl wherein the thienyl is optionally substituted by (1-5C)alkyl;
- Rb and Rc may be the same or different and are each independently selected from the group consisting of hydrogen, (1-10C)alkyl, (3-10C)cycloalkyl, (4-10C)cycloalkylalkyl, (2-10C)alkenyl, (2-10C)alkynyl, (2-10C)alkoxyalkyl, (2-10C)hydroxyalkyl, (3-10C)hydroxycycloalkyl, (4-10C)hydroxycycloalkylalkyl, (2-10C)haloalkyl having one to five halo group(s) wherein the halo group(s) is selected from chloro and fluoro, (3-6C)haloalkenyl having one to five halo group(s) wherein the halo group is selected from chloro and fluoro, phenyl and benzyl;
- or Rb and Rc taken together form a (3-10C)alkylene and together with the nitrogen to which they are attached form a ring;
- Rd is selected from the group consisting of hydrogen, (1-6C)alkyl and (1-6C)alkanoyl;
- and
- pharmaceutically acceptable acid addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.