Method of inactivating reproducible filterable pathogens in blood plasma products

A method of inactivating reproducible filterable pathogens in blood plasma products, wherein said blood plasma products are heat treated in solid state, which method comprises the combination of the following consecutive steps:

• moistening the blood plasma products with water vapor under vacuum in a moistening container, to adjust the blood plasma products to a water content of from 0.08 to 0.40 (8 to 40% by weight),
• equilibrating the thus moistened blood plasma products,
• placing the equilibrated, moistened blood plasma products into an inactivation container,
• subsequently introducing, under vacuum, into said inactivation container, an organic compound selected from the group consisting of ethanol, acetic acid ethyl ester, diethyl ether, dimethylformamide, toluene, chloroform, n-heptane, 1,2-diacetoxy ethane and acetone, to attain a concentration of from 0.01 to 10 g of the organic compound per liter of inactivation container volume, and
• heat treating the blood plasma products in the inactivation container at a temperature and for a period of time sufficient to inactivate the reproducible filterable pathogens,
• the water remaining substantially physically bound to the blood plasma products, while the organic compounds stay in gaseous phase.

A method of inactivating reproducible filterable pathogens in blood plasma products, wherein said blood plasma products are heat treated in solid state, which method comprises the combination of the following consecutive steps:

• moistening the blood plasma products with water vapor under vacuum in a moistening container, to adjust the blood plasma products to a water content of from 0.08 to 0.40 (8 to 40% by weight),
• equilibrating the thus moistened blood plasma products, placing the equilibrated, moistened blood plasma products into an inactivation container,
• sweeping said inactivation container with dry nitrogen,
• subsequently introducing, under vacuum, into said inactivation container, an organic compound selected from the group consisting of ethanol, acetic acid ethyl ester, diethyl ether, dimethylformamide, toluene, chloroform, n-heptane, 1,2-diacetoxy ethane and acetone, to attain a concentration of from 0.01 to 10 g of the organic compound per liter of inactivation container volume,
• introducing dry nitrogen into the inactivation container to obtain ambient pressure therein, and
• heat treating the blood plasma products in the inactivation container at a temperature and for a period of time sufficient to inactivate the reproducible filterable pathogens,
• the water remaining substantially physically bound to the blood plasma products, while the organic compounds stay in gaseous phase.