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US 4,904,592 AGranted
Stabilized enzymes
AssigneeRamot University for Applied Research and Industrial Development Ltd.
InventorsAmihay Freeman, Ruth Tor
Life of this patent
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Abstract
Enzymes are stabilized by encagement in a double layer having a polyaldeh base coat linked to the amino groups of the enzyme, and an outer polymer coat crosslinked therewith. The outer coat is made of a polymer which in the unlinked state has free amino and/or acyl hydrazide groups. Optionally the stabilized enzyme is immobilized within a matrix. Processes for the preparation of the encaged and optionally immobilized enzymes are described.
Claims16
A stabilized, biologically active, water-soluble enzyme product, comprising
- enzyme molecules having a bi-layer protective structure comprising
- a polyaldehyde base coat linked to free amino groups of the enzyme, and cross-linked therewith an outer polymer coat,
- the polymer constituting said outer coat being of a kind which in the unlinked state comprises at least one of free amino and acyl hydrazide groups.
Dependencies are inferred from the claim text.