Radiation compatible iodine formulation
AssigneeBecton, Dickinson and Company
InventorsMohammed A. Khan, John F. Moellmer
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Abstract
A germicidal iodine-containing composition includes iodine, an iodophor, cupric ions and nitrite ions in an aqueous base. Iodide ions which form in the composition during radiation sterilization or prolonged shelf life are oxidized back to iodine by the cupric ions in a Ph dependent reaction which consumes hydrogen ions formed concurrently with the iodide ions. Cuprous ions formed during the oxidation are spontaneously cycled back to cupric ions by traces of air present in the composition. The composition may include nitrite ions to augment the conversion of cuprous ions back to the cupric form.
Claims14
A germicidal iodophor composition comprising an aqueous solution of about 1 to 20% by weight of povidone iodine having about 9-12% by weight iodine therein, about 0.001 to 0.1% by weight of a soluble cupric salt and about 0.001 to 0.1% by weight of a water soluble oxidizing agent, said cupric salt being capable of oxidizing iodide ions in said composition to iodine, said oxidizing agent being capable of oxidizing cuprous ions to cupric ions, whereby the pH and the iodine concentration in said composition remain substantially unchanged.
A germicidal iodophor composition comprising:
- an aqueous solution of about 6 to 12% by weight of povidone iodine, about 1 to 10% by weight of a nonionic surfactant, a buffer adapted to maintain the pH of said solution from 5 to 6.5, about 0.01 to 0.1% by weight of a soluble cupric salt and about 0.01 to 0.1% by weight of a nitrite salt, said cupric salt being capable of oxidizing iodide ions in said composition to iodine, said nitrite salt being capable of oxidizing cuprous ions to cupric ions, whereby the pH and the iodine concentration in said composition remain substantially unchanged.
Dependencies are inferred from the claim text.