Process for the manufacture of optically active compounds
AssigneeHoffmann-La Roche Inc.
InventorsHans-Jurgen Hansen, Rudolf Schmid, Max Schmid
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Abstract
The manufacture of optically active bifunctional compounds of the general formula ##STR1## wherein R represents protected hydroxymethyl, protected formyl or alkoxycarbonyl and R.sup.1 represents a group of the formula ##STR2## in which R.sup.2 and R.sup.3 represents lower alkyl or cycloalkyl or R.sup.2 and R.sup.3 together with the nitrogen atom represent a heterocyclic ring, by isomerizing compounds of the general formula ##STR3## wherein R, R.sup.2 and R.sup.3 have the above significance and R.sup.3 can additionally signify hydrogen, is described. The compounds of formula I are potential intermediates in the manufacture of, interalia, natural vitamin E and natural vitamin K.sub.1.
Claims3
An optically active bifunctional compound of the formula:
- ##STR19## wherein R is protected formyl or alkoxycarbonyl;
- and R.sup.1 is ##STR20## in which R.sup.2 and R.sup.3 individually are lower alkyl or cycloalkyl or R.sup.2 and R.sup.3 taken together with the nitrogen atom of Ia form a mononuclear hydrocarbon ring of 3 to 8 carbon atoms containing at least one hetero atom selected from O, N or S;
- said protected formyl having the formula:
- ##STR21## wherein A is C.sub.1 -C.sub.4 -alkyl or both A groups taken together are C.sub.2 -C.sub.4 -alkylene.
Dependencies are inferred from the claim text.