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US 4,902,808 AGranted
Process for preparing 4-carboxy-1-(3,5-dimethylphenyl)-5-pyrazolecarboxamide
AssigneeEli Lilly and Company
InventorsStephen A. Ackmann, James R. Beck, Fred L. Wright
Life of this patent
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Abstract
Use of a 4,5-dicarboxy or 5-carboxamido-4-carboxy (or derivatized carboxy)-1-(3,5-disubstituted-phenyl)pyrazole in the production of hybrid seed, and a method for producing 5-carboxamido-4-carboxy-1-(3,5-dimethylphenyl)pyrazole.
Claims1
A process for preparing a compound of the formula ##STR3## which comprises the steps of (a) reacting a compound of formula (3) ##STR4## where R.sup.2 alkoxy and R.sup.4 is NH.sub.2, with dimethylsulfide in the presence of t-butyl nitrite to provide the corresponding compound of formula (3) wherein R.sup.4 is SCH.sub.3,
- (b) oxidizing the resulting intermediate to provide the corresponding compound of formula (3) wherein R.sup.4 is --SO.sub.2 CH.sub.3,
- (c) reacting the product of step (b) with an alkali metal cyanide to provide the corresponding compound of formula (3) wherein R.sup.4 is CN, and
- (d) hydrolyzing the product of step (c).
Dependencies are inferred from the claim text.