Bicyclic alkoxy- and alkylthio-substituted aminoalcohols
AssigneeMaggioni-Winthrop S.p.A.
InventorsGiampaolo Picciola, Mario Riva, Franco Ravenna, Piergiorgio Gentili
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Abstract
Novel bicyclic alkoxy- and alkylthio-substituted aminoalcohols of formula (I). The compounds show anti-hypertensive, platelet aggregation inhibiting, hypolipemic, antianoxic, spasmolytic, antithrombotic, calcium antagonizing and neuroleptic activity.
Claims6
A compound of the formula:
- ##STR19## wherein R represents a lower straight or branched alkyl group, X represents --O-- or --S--, n is an integer from 1 to 3, R.sub.1 represents hydrogen or a lower alkyl group;
- R.sub.2 represents hydrogen or benzyl;
- R.sub.3 represents an alkyl group;
- or alternatively R.sub.2 and R.sub.3 taken together represent a divalent group selected from:
- (a) ##STR20## wherein Y represents hydrogen or halogen;
- and (b) ##STR21## wherein A is a group selected from ##STR22## wherein R.sub.4 represents a lower alkyl group and its salts with inorganic acids, organic acids, cationic exchange resins and complexes with cyclodextrins.
A compound selected from the stereoisomeric threo and erythro form of 2-[4-(2-oxo-1-benzimidazolinyl)-1-piperidinyl]-1-(6-methoxy-2-naphthyl)-pr opanol.
2-[4 -(2-Oxo-1-benzimidazolinyl)-1-piperidinyl]-1-(6-methoxy-2-naphthyl)ethanol.
A compound selected from the steroisomeric threo and erythro form of 2-(4-benzamido-1-piperidinyl)-1-(6-methoxy-2-naphthyl)-propanol.
A compound selected from the stereoisomeric threo and erythro form of 2-[4-(2-Oxo-1-benzimidazolinyl)-1-piperidinyl]-1-(6,7-dimethoxy-2-naphtyl) -propanol.
A compound of the formula:
- ##STR23## wherein R represents a lower straight or branched alkyl group, X represents --O-- or --S--, n is an integer from 1 to 3, R.sub.1 represents hydrogen or a lower alkyl group;
- R.sub.2 represents hydrogen or benzyl;
- R.sub.3 represents an alkyl group;
- or alternatively R.sub.2 and R.sub.3 taken together represents a divalent group selected from:
- (a) ##STR24## wherein Y represents hydrogen or halogen;
- and (b) ##STR25## wherein A is is a group selected from ##STR26## wherein R.sub.4 represents a lower alkyl group.
Dependencies are inferred from the claim text.