Nitrosourea derivatives, process for their preparation and medicaments containing them

A nitrosourea derivative of the formula:

• ##STR215## in which:
• R is hydrogen, alkyl of 1 to 30 carbon atoms, aralkyl of 7 to 12 carbon atoms, or aralkyl of 7 to 12 carbon atoms substituted with Hal, --NO.sub.2, NH.sub.2, --CF.sub.3 or alkoxy of 1 to 4 carbon atoms;
• X is hydroxy or --NR.sub.1 R.sub.2 ;
• Y is hydrogen, hydroxy or --NR'.sub.1 R'.sub.2 ;
• R.sub.1 and R'.sub.1 are each hydrogen or ##STR216## Hal is a halogen;
• R.sub.2 and R'.sub.2 are each hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, aryl of 4 to 10 carbon atoms, aralkyl of 7 to 12 carbon atoms, aryl of 4 to 10 carbon atoms substituted with Hal, --NO.sub.2, --NH.sub.2, --CF.sub.3 or alkoxy of 1 to 4 carbon atoms, or aralkyl of 7 to 12 carbon atoms substituted with Hal, --NO.sub.2, --NH.sub.2, --CF.sub.3 or alkoxy of 1 to 4 carbon atoms;
• R' and R" are each hydrogen, hydroxy or --OM;
• and
• M is alkyl of 1 to 30 carbon atoms, aryl of 4 to 10 carbon atoms, aralkyl of 7 to 12 carbon atoms, aryl of 4 to 10 carbon atoms substituted with Hal, --NO.sub.2, --NH.sub.2, --CF.sub.3 or alkoxy of 1 to 4 carbon, aralkyl of 7 to 12 carbon atoms substituted with Hal, --NO.sub.2, --NH.sub.3, --CF.sub.3 or alkoxy of 1 to 4 carbon atoms, acyl of 2 to 8 carbon atoms, aroyl of 5 to 12 carbon atoms, or aroyl of 5 to 12 carbon atoms substituted with Hal, --NO.sub.2, --NH.sub.2, CF.sub.3 or alkoxy of 1 to 4 carbon atoms;
• provided that at least:
• X is --NR.sub.1 R.sub.2 and R.sub.1 is ##STR217## or Y is --NR'.sub.1 R'.sub.2 and R'.sub.1 is ##STR218## and either R' is hydrogen or R" is hydrogen, and R' and R" are not both hydrogen.