Calcium homeostasis compositions and methods for controlling calcium metabolism
OwnerRobert K. Bayless, Gerald P. Hirsch +1inventors
InventorsRobert K. Bayless, Gerald P. Hirsch, Sandra S. Kern
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Abstract
This invention concerns novel calcium normalizing compositions containing as the active agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, and novel methods employing the compositions for normalizing or controlling calcium metabolism. The compounds include the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR1## and pharmaceutically acceptable N- (mono- and dicarboxylic acid) acyl derivatives and alkyl esters thereof, where in is an integer from 1 to 3.
Claims9
A method for normalizing calcium metabolism in a subject in need thereof, comprising administering to the subject active components in dosage form consisting essentially of a daily allowance of a pharmaceutically acceptable calcium agent which provides 0.5 to 1.5 grams of calcium, an a therapeutically effective calcium metabolism normalizing amount of a methionine compound selected from the group consisting of the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR3## and pharmaceutically acceptable N- (mono- and di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.
A method for treating the condition of hypertension in a subject in need of such treatment, comprising administering to the subject on a daily basis a composition consisting essentially of a pharmaceutically acceptable calcium agent and an effective calcium metabolism normalizing amount of 1 to 5 grams per 70 kg body weight a of methionine compound selected from the group consisting of the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR4## and pharmaceutically acceptable N- (monoand di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3, and 0.5 to 5 grams of one of the group consisting of betaine, glycine and serine.
A method for inhibiting growth of calculi in a subject in need of said treatment, comprising administering on a daily basis a composition consisting essentially of a pharmaceutically acceptable calcium agent and an effective calcium metabolism normalizing amount of 0.5 to 5.0 grams per 70 kg body weight of a methionine compound selected from the group consisting of the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR5## and pharmaceutically acceptable N- (monoand di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer form 1 to 3.
A method for treating osteoporosis in a subject in need of said treatment, comprising administering to the subject on a daily basis a composition consisting essentially of a pharmaceutically acceptable calcium agent to provide 0.5 to 1.5 grams of calcium per 70 kg body weight and an effective calcium metabolism normalizing amount of a methionine compound of 0.5 to 5.0 grams per 70 kg body weight selected from the group consisting of the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR6## and pharmaceutically acceptable N- (monoand di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.
Dependencies are inferred from the claim text.