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US 4,902,710 AGranted
Serotonin and norepinephrine uptake inhibitors
AssigneeEli Lilly and Company
InventorsBennie J. Foster, David C. Hunden, Edward R. Lavagnino
Life of this patent
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Abstract
The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, which are capable of selectively inhibiting the uptake of serotonin and norepinephrine.
Claims27
A compound of the formula ##STR21## wherein:
- R is phenyl, substituted phenyl, naphthyl, substituted naphthyl, thienyl, halothienyl, (C.sub.1 -C.sub.4 alkyl)-substituted-thienyl, furanyl, halofuranyl, (C.sub.1 -C.sub.4 alkyl)-substituted-furanyl, pyrrolyl, halopyrrolyl or (C.sub.1 -C.sub.4 alkyl)-substituted-pyrrolyl;
- R.sup.1 is phenyl, substituted phenyl, C.sub.5 -C.sub.7 cycloalkyl, thienyl, halothienyl, (C.sub.1 -C.sub.4 alkyl)-substituted-thienyl, furanyl, pyridyl or thiazolyl;
- R.sup.2 and R.sup.3 are each independently hydrogen or methyl;
- n is 0, 1 or 2;
- and
- the pharmaceutically acceptable acid addition salts thereof.
3 more elements
Dependencies are inferred from the claim text.