Novel antihypercholesterolemic compounds

A compound of structural formula (II):

• ##STR12## wherein Z is phenyl, naphthyl, thiophenyl, pyrryl;
• or phenyl, naphthyl, thiophenyl, pyrryl substituted with a group A;
• A is selected from a group consisting of:
• Cl, F, OH, C.sub.1-5 alkyl, C.sub.1-5 alkyloxy, C.sub.2-8 alkanoyloxy, C.sub.2-6 alkanoylamino, C.sub.1-5 alkyloxycarbonyl, phenyl, hydroxy-C.sub.1-5 alkyl, trifluromethyl-C.sub.2-8 alkanoylamino;
• E is a direct bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- R.sub.1, R.sub.2, R.sub.3 are each selected from:
• H, Cl, or F, C.sub.1-4 alkyl, C.sub.1-4 chloroalkyl or C.sub.1-4 fluroalkyl, phenyl, phenyl substituted by Cl or F, C.sub.1-4 alkyloxy. C.sub.2-8 alkanoyloxy C.sub.2-8 -Balkanoyloxy-C.sub.1-5 alkyl, and
• OR.sub.4 in which R.sub.4 is H, C.sub.2-8 alkanoyl, benzoyl phenyl, chlorophenyl or flurophenyl, phenyl-C.sub.1-3 alkyl, C.sub.1-8 alkyl, C.sub.1-4 chloroalkyl or C.sub.1-4 fluroalkyl, cycloalkyl-C.sub.1-3 alkyl, adamantyl-C.sub.1-3 alkyl, or substituted Phenyl-C.sub.1-3 alkyl in which the substituents are selected from:
• chlorine or fluorine, C.sub.1-4 alkyloxy, C.sub.1-4 alkyl, C.sub.1-4 chloroalkyl or C.sub.1-4 fluroalkyl;
• R.sub.5 is hydrogen, C.sub.1-5 alkyl or C.sub.1-5 alkyl substituted with a member of the group consisting of phenyl, dimethylamino, or acetylamino;
• and
• a pharmaceutically acceptable salt of the compound (II) in which R.sub.5 is hydrogen.