Thiazole derivative and leukotriene antagonist containing the same as the effective ingredients

A leukotriene antagonist composition comprising:

• a pharmaceutically effective amount of a thiazole derivative represented by the following formula or a pharmaceutically acceptable salt thereof as the active ingredient:
• ##STR350## wherein R.sub.1 and R.sub.2 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a lower alkoxycarbonyl group or a phenyl group which is unsubstituted or substituted with a halogen atom, a lower alkoxy group, a lower alkoxycarbonyl group or an alkyl group having 1 to 3 carbon atoms or wherein R.sub.1 and R.sub.2 cooperate to represent a tetramethylene group corresponding to a fused cyclohexane ring or a butadienylene group which is unsubstituted or substituted with a halogen atom, a lower alkoxy group, a lower alkoxycarbonyl group or an alkyl group having 1 to 3 carbon atoms corresponding to a fused benzene ring;
• R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, an alkyl group having 1 to 3 carbon atoms or a halogen atom;
• A is a linking group selected from the group consisting of --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, --CH.dbd.CHCONH-- and --CH.sub.2 OCH.sub.2 --;
• B is a group selected from the group consisting of (a) --(CH.sub.2).sub.n --CONH--, wherein n is an integer of 1-3, (b) --(CH.sub.2).sub.n --NH--, wherein n is an integer of 1-4, (c) --(CH.sub.2).sub.n --O--, wherein n is an integer of 1-4, (d) --(CH.sub.2).sub.n --, wherein n is an integer of 2-5, ##STR351## wherein R.sub.7 and R.sub.8 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms as defined above, ##STR352## wherein R.sub.7 and R.sub.8 have the same meanings as defined above, ##STR353## wherein R.sub.7 and R.sub.8 have the same meanings as defined above, ##STR354## wherein R.sub.9, R.sub.10, R.sub.11 and R.sub.12 each independently represent a hydrogen atom, a phenyl group or an alkyl group having 1 to 6 carbon atoms, ##STR355## wherein R.sub.9, R.sub.10, R.sub.11 and R.sub.12 have the same meanings as defined above, ##STR356## wherein R.sub.9, R.sub.10, R.sub.11 and R.sub.12 have the same meanings as defined above and m ranges from 0 to 3, ##STR357## wherein R.sub.9 and R.sub.11 have the same meanings as defined above, ##STR358## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR359## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR360## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR361## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR362## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR363## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR364## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR365## wherein R.sub.10 and R.sub.12 have the same meanings as defined above, ##STR366## wherein R.sub.11 and R.sub.12 have the same meanings as defined above, and ##STR367## wherein R.sub.11 and R.sub.12 have the same meanings as defined above;
• and Q represents a carboxyl group, a lower alkoxy group, a hydroxyl group, an alkoxycarbonyl group having 2 to 6 carbon atoms or a 5-tetrazolyl group, in combination with a pharmaceutically acceptable excipient.