US 4,902,699 AGranted

Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as medicaments and the compositions containing them

AssigneeRoussel Uclaf

InventorsEmilio Toja, Carla Bonetti, Fernando Barzaghi, Giulio Galliani

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Abstract

Compounds useful in the treatment of patients suffering from senile dementia, Alzheimer's disease or memory defects, of the formula ##STR1## in which R represents hydrogen or a linear, branched or cyclic alkyl, alkenyl, or alkynyl, containing up to 8 carbon atoms, or the radical ##STR2## in which R.sub.1 represents a linear or branched, alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, a linear or branched, saturated or unsaturated, alkoxy containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or the radical ##STR3## in which R.sub.2 represents a linear or branched alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, aryl containing up to 14 carbon atoms, possibly substituted, or aralkyl containing up to 18 carbon atoms, possibly substituted, and R' represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, as well as their addition salts with organic or mineral acids.

Claims10

Dependent claims

Compounds of the formula (I) ##STR10## in which R is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, n-pentyl, n-hexyl, tert-butyl, tert-pentyl, neopentyl, ethylene radical, acetylene radical, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, phenyl which is unsubstituted or substituted with halogen, alkyl having up to 8 carbon atoms or alkoxy having up to 8 carbon atoms, --COCH.sub.3, ##STR11## --CONH--R.sub.2 and COR.sub.1, in which R.sub.1 is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, alkoxy having up to 8 carbon atoms, n-pentyl, n-hexyl, tert-butyl, tert-pentyl, neopentyl, ethylene radical or acetylene radical, and

R.sub.2 is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, n-pentyl, n-hexyl, tert-butyl, tert-phenyl, neopentyl, ethylene radical, acetylene radical, phenyl which is unsubstituted or substituted with halogen, alkyl having up to 8 carbon atoms or alkoxy having up to 8 carbon atoms, and phenalkyl, which is unsubstituted or substituted with halogen, alkyl having up to 8 carbon atoms or alkoxy having up to 8 carbon atoms, and
R' is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, n-pentyl, n-hexyl, tert-butyl, tert-pentyl, neopentyl, ethylene radical, acetylene radical, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl and cyclohexylmethyl.

Dependencies are inferred from the claim text.