Dihydropyridine calcium channel modulators
AssigneeEli Lilly and Company
InventorsDonald R. Holland, James H. Wikel
Life of this patent
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Abstract
4-[Thieno[3,2-c]pyridinyl]-pyridinecarboxylic acid esters as calcium channel modulators, methods of use and pharmaceutical compositions therefor.
Claims12
A compound of the formula ##STR5## and pharmaceutically acceptable salts thereof wherein R.sup.1 is a straight or branched chain, saturated or unsaturated aliphatic radical containing from one to six carbon atoms, both inclusive, optionally substituted with one or more groups selected from phenyl, methoxy-substituted phenyl, phenoxy, methoxy or cyclopropyl;
- or R.sup.1 is cyanoethyl.
A method of treating congestive heart failure in a mammal in need thereof comprising administering to said mammal an effective amount of a compound of the formula ##STR6## and pharmaceutically acceptable salts thereof wherein R.sup.1 is a straight or branched chain, saturated or unsaturated aliphatic radical containing from one to six carbon atoms, both inclusive, optionally substituted with one or more groups selected from phenyl, methoxy-substituted phenyl, phenoxy, methoxy or cyclopropyl;
- or R.sup.1 is cyanoethyl.
A pharmaceutical formulation for use in treating congestive heart failure comprising an effective amount of a compound of the formula ##STR7## and pharmaceutically acceptable salts thereof wherein R.sup.1 is a straight or branched chain, saturated or unsaturated aliphatic radical containing from one to six carbon atoms, both inclusive, optionally substituted with one or more groups selected from phenyl, methoxy-substituted phenyl, phenoxy, methoxy or cyclopropyl;
- or R.sup.1 is cyanoethyl in admixture with one or more pharmaceutically acceptable carriers, diluents or excipients therefor.
Dependencies are inferred from the claim text.