Back to results
US 4,902,691 AGranted
Heteroalkylamides of (8-.beta.)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT.sub.2 receptors
AssigneeEli Lilly and Company
InventorsMarlene L. Cohen, David W. Robertson
Life of this patent
Estimating the term…
Abstract
This invention provides (8.beta.)-N-heteroalkyl-1-alkyl-6-(substituted)ergoline-8-carboxamides useful for blocking 5HT.sub.2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hypertension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.
Claims25
A compound of the formula
- wherein:
- R.sup.1 is C.sub.1 -C.sub.4 alkyl;
- R.sup.2 is allyl or C.sub.1 -C.sub.4 straight chain alkyl;
- R.sup.3 is hydrogen or C.sub.1 -C.sub.4 straight chain alkyl;
- R.sup.4 is pyridinyl or imidazolyl;
- alk is a divalent organic radical derived from a straight or branched C.sub.1 -C.sub.5 alkane;
- or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.