Inhibition of immune clearance using progesterone analogues
AssigneeUniversity of Pennsylvania
InventorAlan D. Schreiber
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Abstract
Clearance of antibody-coated cells from the circulation of mammals is inhibited by administering an effective amount of 17-hydroxyprogesterone or 16-methylprogesterone. The compounds are useful in treating autoimmune disease.
Claims13
A method of inhibiting the clearance of antibody-coated cells from the circulation of mammals comprising administering to a mammal exhibiting undesired clearance of antibody-coated cells an effective amount of a compound selected from the group consisting of 17-hydroxyprogesterone and 16-methylprogesterone.
A method of treating immune throbocytopenic purpura comprising administering to a mammal having such disease an effective amount of a compound selected from the group consisting of 17-hydroxyprogesterone and 16-methylprogestrone.
A method of treating immune hemolytic anemia comprising administering to a mammal having such disease an effective amount of a compound selected from the group consisting of 17-hydroxyprogestrone and 16-methylprogestrone.
Dependencies are inferred from the claim text.