Treatment of heart failure of mammals with N.sup.6 -substituted cyclic adenosine monophosphates
AssigneeKikkoman Corporation
InventorsShoichi Imai, Shigehiro Kataoka, Junko Isono, Nobuyuki Yamaji, Motohiko Kato
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Abstract
A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N.sup.6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable salt thereof: ##STR1## wherein R represents alkyl or aralkyl group and a pharmaceutically acceptable carrier, as well as a method for treating heart failure of mammals which comprises administering said composition.
Claims9
A method for the treatment of heart failure of a mammal which comprises administering, per kilogram of body weight of said mammal, 0.002 to 60 mg per day of an N.sup.6 -substituted-adenosine-3',5'-cyclic phosphate represented by the following general formula or a physiologically acceptable salt thereof:
- ##STR3## wherein R represents an alkyl group selected from the group consisting of ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, isopentyl, hexyl, isohexyl, cyclohexyl, heptyl, isoheptyl, octyl, isooctyl, nonyl, isononyl, decyl, undecyl, dodecyl, tridecyl, and tetradecyl group, or an aralkyl group selected from the group consisting of furfuryl, benzyl, phenethyl, chlorobenzyl, hydroxybenzyl, methylbenzyl and methoxybenzyl.
Dependencies are inferred from the claim text.