Process for the preparation of capsular polysaccharides of staphylococci, the polysaccharides obtained, uses of these polysaccharides and strains for carrying out of the process
AssigneeInstitut Pasteur
InventorsJean-Michel Fournier, Anne Bouvet, Alain Boutonnier
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Abstract
The subject of the invention is a process for the preparation of capsular polysaccharides characteristic of Staphylococcus aureus, comprising the use of coagulase-negative strains of staphylococci for the preparation of these polysaccharides. The capsular polysaccharides obtained can be used for the preparation of vaccines against Staphylococcus aureus and diagnostic agents.
Claims15
A process for the preparation of capsular polysaccharides characteristic of Staphylococcus aureus, comprising using strains of coagulase-negative staphylococci which have the ability to produce capsular polysaccharides.
A process for the preparation of capsular polysaccharides characteristic of Staphylococcus aureus, said process comprising:
- (a) selecting from coagulase-negative strains of staphylococci a strain which is capable of producing a capsular polysaccharide characteristic of Stapylococcus aureus,
- (b) culturing the selected strain from (a),
- (c) extracting the capsular polysaccharide from said cultured selected strains, and
- (d) purifying the capsular polysaccharide.
Capsular polysaccharide characteristic of Staphylococcus aureus and obtained from strains of coagulase-negative staphylococci.
Vaccine against Staphylococcus aureus comprising a capsular polysaccharide characteristic of Staphylococcus aureus and obtained from strains of coagulase-negative staphylococci.
Purified strains of coagulase-negative staphylococci producing capsular polysaccharides characteristic of Staphylococcus aureus.
A diagnostic agent for the detection of coagulase-positive or coagulase-negative staphylococci comprising a capsular polysaccharide characteristic of Staphylococcus aureus which is obtained from strains of coagulase-negative staphylococci.
Dependencies are inferred from the claim text.