Chimeric peptides for neuropeptide delivery through the blood-brain barrier
AssigneesAlkermes, Inc., The Regents of the University of California
InventorsWilliam M. Pardridge, Paul R. Schimmel
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Abstract
Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the blood-brain barrier by transcytosis at a relatively high rate. The transportable peptide is conjugated to a hydrophilic neuropeptide which by itself is transportable only at a very low rate into the brain across the blood-brain barrier. The resulting chimeric peptide is transported into the brain at a much higher rate than the neuropeptide alone to thereby provide an effective means for introducing hydrophilic neuropeptides into the brain through the blood-brain barrier.
Claims18
A chimeric peptide adapted for delivering a neuropharmaceutical agent into the brain by transcytosis through the blood-brain barrier, said chimeric peptide comprising a transportable peptide capable of crossing the blood-brain barrier by transcytosis conjugated with said neuropharmaceutical agent, wherein said transportable peptide is histone.
In a method for introducing a hydrophilic neuropeptide into the brain across the blood-brain barrier, wherein the improvement comprises increasing the rate at which said neuropeptide crosses the blood-brain barrier by conjugating said neuropeptide with histone.
Dependencies are inferred from the claim text.