Stabilization of antibodies
AssigneeAkzo N.V.
InventorsTheodorus Jansen, Engelbertus J. M. Janssen, Lammert Cornelius
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Abstract
According to the present invention antibody preparations are more stable during storage if in addition they contain a mixture of at least one polyoxypropylene-polyoxyethylene block polymer (such as Pluronic F68) and at least one phospholipid (such as lecithin).
Claims11
Stable aqueous solution of antibodies, comprising antibodies and at least one polyoxypropylene-polyoxyethylene block polymer and at least one phospholipid in amounts effective to prevent the formation of antibody aggregates or antibody sedimentation.
A method for stabilizing aqueous solutions of antibodies, comprising mixing with the solution at least one polyoxypropylene-polyoxyethylene block polymer in an amount to achieve concentration of 0.01-5% by weight polyoxypropylene-polyoxyethylene block polymer and at least one phospholipid in an amount to achieve a concentration of 0.001-1% by weight phospholipid, whereby the formation of antibody aggregates and the sedimentation of antibodies is prevented.
Dependencies are inferred from the claim text.