IgE Fc directed delivery system
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsMichael A. Kaliner, Howard Boltansky
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Abstract
An immunotoxin comprising a conjugate of a toxin with immunoglobulin E or a part thereof and a method delivering the same to a target site is described. Mast cell related abnormalities can be detected by the immunotoxin of the present invention.
Claims7
An immunotoxin comprising a conjugate of a toxin with immunoglobulin E (IgE) or a part thereof, said conjugate being capable of binding specifically with IgE Fc receptors with an affinity of equal or greater than 10.sup.9 M.sup.-1, said conjugate being suitable for use in vivo, wherein said toxin is bismuth.sup.212 or indium.sup.111.
A method of delivering a toxic agent to a target cell or tissue located in a host, wherein said cell or tissue expressing IgE Fc receptors of equal or greater than 10.sup.9 M.sup.-1 binding affinity comprising conjugating a toxic agent with monomeric or intact immunoglobulin E or a portion thereof, wherein said conjugate possesses an Fc fraction and administering an effective amount of said conjugate to said host.
A method of detecting mast cell tumors, benign mastocytosis or mast cell number comprising systemically delivering an effective amount of a conjugate of IgE Fc and a radiolabeled agent to a host suspected of having a mast cell tumor, benign mastocytosis or disease process involving mast cells, and obtaining a radiographic image of said host or of a body part thereof.
Dependencies are inferred from the claim text.