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US 4,902,296 AGranted
Use of demineralized bone matrix in the repair of segmental defects
AssigneeThe University of Virginia Alumni Patents Foundation
InventorsMark E. Bolander, Gary Balian
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Abstract
A grafting material comprising milled bone which has an initial coating of guanidine-extracted bone proteins which are dialyzed from solution. Unbound bone proteins are removed and this augmented milled bone is lyophized. A subsequent coat of anti-coagulated plasma containing plasma proteins is applied to the augmented milled bone. The unbound plasma proteins are removed from the coating by rinsing.
Claims4
Biological grafting material, comprising:
- milled bone initially coated with guanidine-extracted bone proteins which are dialyzed from solution, wherein unbound bone proteins are removed;
- and
- subsequently coated with anti-coagulated plasma containing plasma proteins, wherein unbound plasma proteins are removed.
Dependencies are inferred from the claim text.