Process for the preparation of a vessel prosthesis impregnated with crosslinked gelatin
AssigneeB. Braun-SSC AG
InventorsPeter Fleckenstein, Heinz-Helmut Werner
Life of this patent
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Abstract
The invention relates to a process to prepare vessel prostheses formed from a porous basic body and an impregnating coating of crosslinked gelatin for sealing the pores. Crosslinking takes place accompanied by the use of a diisocyanate. The impregnating coating has good mechanical and physiological properties.
Claims10
A process for producing impregnated vessel prostheses, wherein a porous vessel prosthesis is impregnated with an aqueous gelatin solution, the gelatin solution is allowed to gel, the gelatin solution is then carefully partially dehydrated and then the impregnating coating obtained is crosslinked with a diisocyanate.
A process for producing an impregnated vessel prosthesis, which comprises the steps of:
- (a) impregnating a porous vessel prosthesis with an aqueous gelatin solution;
- (b) allowing the gelatin solution to gel;
- (c) partially dehydrating the gelatin solution to obtain an impregnating coating;
- and
- (d) crosslinking the impregnating coating by applying thereto a solution of 0.03 to 3% by weight of diisocyanate, 0 to 60% by weight of plasticizer, 30 to 95% by weight of solvent, and 5 to 70% by weight of water, the quantity ratios being matched to one another so that the diisocyanate is present in the dissolved state.
A process for producing an impregnated vessel prosthesis, which comprises the steps of:
- (a) impregnating a porous vessel prosthesis with an aqueous gelatin solution;
- (b) allowing the gelatin solution to gel;
- (c) partially dehydrating the gelatin solution to obtain an impregnating coating;
- and
- (d) crosslinking the impregnating coating by applying thereto a solution containing a diisocyanate wherein the crosslinking solution is constantly circulated during the crosslinking reaction and insoluble by-products are removed by filtration.
Dependencies are inferred from the claim text.