Process for the purification of N-acylaspartame
AssigneeHoechst Aktiengesellschaft
InventorsErwin Schmidt, Reinhold Keller
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Abstract
The .alpha.-linked dipeptide formed from aspartic acid and phenylalanine ester can be separated very well from the corresponding .beta.-linked component by recrystallizing the mixture from a buffered, aqueous solution.
Claims7
A process for the separation of a mixture of compounds of the formulas I and II ##STR4## in which R.sup.1 denotes an amino protective group and R.sup.2 represents an alkyl radical having 1 to 4 carbon atoms, which comprises buffering a mixture of compounds of the formulas I and II to a suitable pH range such that the compounds of one of formulas I and II are at least partially in a solution and the compounds of the other of the formulas are not in the solution, with the proviso that said buffering does not include the use of zinc salts.
Dependencies are inferred from the claim text.