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US 4,900,828 AGranted
Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
AssigneeHoffmann-LaRoche Inc.
InventorsPeter S. Belica, Tai-Nang Huang, Percy S. Manchand, John J. Partridge, Steve Tam
Life of this patent
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Abstract
A method for the synthesis of 2',3'-dideoxycytidine comprising a novel procedure of bromoacetylating cytidine to yield novel intermediates which are subsequently reduced and hydrogenated by novel procedures to yield 2',3'-dideoxycytidine.
Claims21
A compound of the formula:
- ##STR25## wherein R' is substituted or unsubstituted lower alkyl, aryl, or aralkyl with the substituents selected from the group consisting of halogen, alkyl, nitro, or alkoxy;
- and R is substituted or unsubstituted 2-acetoxy-2-methylpropanoyl, 2-acetoxypropanoyl, or 2-acetoxybenzoyl with the substituents selected from the group consisting of lower alkyl, aryl, or aralkyl.
Dependencies are inferred from the claim text.