Hemoglobin complexes
AssigneeFisons Limited
InventorJeffrey T. Wong
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Abstract
There is described a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000 and having the formula I, B--X--(PS)--X--(H) I in which PS is a polysaccharide of molecular weight from about 2,000 to about 2,000,000, X is a covalently bonded chemical bridging group, H is a group Hb or Hb--Z B is a blocked activating group Hb is a hemoglobin residue, and Z is an oxygen affinity reducing ligand containing two or more phosphate groups. There are also described processes for making the compounds, and their formulations and use as oxygen transporting agents.
Claims5
A water soluble compound having a molecular weight of from about 70,000 to about 2,000,000 and having the formula I,
- B--X--(PS)--X--(H) I
- in which PS is a polysaccharide of molecular weight from about 2,000 to about 2,000,000,
- X is a covalently bonded chemical bridging group,
- H is a group Hb or Hb-Z,
- B is an activating group blocked by a sulphydryl group,
- Hb is a haemoglobin residue, and
- Z is an oxygen affinity reducing ligand containing two or more phosphate groups.
Dependencies are inferred from the claim text.