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US 4,900,815 AGranted
Sulfated polysaccharide DS4152
AssigneeDaiichi Seiyaku Co., Ltd.
InventorsNoriko Tanaka, Kazuhiro Inoue, Hiroshi Korenaga, Hidemasa Ogawa
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AssigneeDaiichi Seiyaku Co., Ltd.
InventorsNoriko Tanaka, Kazuhiro Inoue, Hiroshi Korenaga, Hidemasa Ogawa
Estimating the term…
A sulfated polysaccharide DS4152 useful as an angiogenesis inhibitor or antitumor agent is provided selectively. As the sodium salt, it has the following physicochemical characteristics. Molecular weight by the gel filtration method: 29,000.+-.3,000. Elemental analysis: C: 24.42-25.76%, H: 3.34-3.98%, N: 0.51-0.89%, S: 10.6-11.7% and P: 0.77-1.06%. Sugar and protein contents: Sugar content (%): 57.+-.3 (by phenol sulfuric acid method; standard: galactose). Protein content (%): 1.+-.0.5 (by the Lowry-Folin's method; standard: bovine serum albumin). Specific rotatory power [.alpha]sub.D.sup.25 : -37.degree..+-.1.degree. (0.5% aq. solution). Characteristic absorption bands in infrared absorption spectrum: 1240, 840 (shoulder), 810 (cm.sup.-1 ; KBr).
A sulfated polysaccharide DS4152 having, as the sodium salt thereof, the following physicochemical characteristics:
An angiogenesis inhibitor comprising an effective amount of a sulfated polysaccharide DS4152 as the active ingredient and a medicinally-acceptable carrier or excipient.
An antitumor agent comprising a sulfated polysaccharide DS4152 as the active ingredient and a medicinally-acceptable carrier or excipient.
An angiogenesis inhibitor comprising, as active ingredients, a sulfated polysaccharide DS4152 and a steroid or antiestrogen.
An antitumor agent comprising, as active ingredients, a sulfated polysaccharide DS4152 and a steroid or antiestrogen.
A method for inhibiting angiogenesis, which comprises administering to a subject an effective amount of sulfated polysaccharide DS4152.
Dependencies are inferred from the claim text.