Acellular resuscitative fluid
AssigneeMasonic Medical Research Laboratory
InventorLawrence C. Cerny
Life of this patent
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Abstract
An acelluar resuscitative fluid, useful as an artificial blood or blood substitute, is prepared from a modified, high molecular weight starch or a tetronic polyol prepared by the interaction of ethylenediamine and ethylene or propylene oxides, which are converted to their aldehyde form. This material is reacted with a stabilized, stroma free hemoglobin, which has been converted to an oxy-acid or diketone. The resulting solution, after purification, can be administered to an animal in the same manner as whole blood. If desired, the solution of the reaction product with the stabilized hemoglobin can be freeze-dried and later reconstituted by the addition of water to provide the administrable fluid.
Claims20
An acellular resuscitative fluid comprising the reaction product of:
- (a) A stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxyacids and diketones;
- and
- (b) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of:
- (1) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons;
- and
- (2) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine.
A powdered acellular resuscitative material formed by freeze-drying the reaction product of:
- (a) a stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxy-acids and diketones;
- and
- (b) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of:
- (1) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons;
- and
- (2) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine.
A method for forming a powdered acellular resuscitative material comprising:
- a. reacting
- (1) A stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxyacids and diketones;
- and
- (2) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of:
- (a) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons;
- and
- (b) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine;
- and
- b. freeze-drying the resulting material.
Dependencies are inferred from the claim text.