Solubilization of complexes of water-insoluble organic compounds by aqueous solutions of polyvinylpyrrolidone
AssigneeGAF Chemicals Corporation
InventorsTerry E. Smith, James R. Cho, Ian W. Cottrell
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Abstract
A method for increasing the water-solubility of highly insoluble organic compounds by forming a complex product from the reaction between the organic compound and an aqueous solution of solid polyvinylpyrrolidone. The solubility of the organic compound can be increased at least 25-fold and the complex formed is highly stable at ambient conditions.
Claims10
A method for preparing a water-soluble complex of a water-insoluble organic compound selected from the group consisting of furosemide, chlorhexidine and trifluralin, comprising dissolving solid polyvinylpyrrolidone in water, suspending the organic compound in the solution and heating the suspension at a temperature and for a period of time sufficient to dissolve the organic compound.
Dependencies are inferred from the claim text.