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US 4,900,756 AGranted
(2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes
AssigneeAmerican Cyanamid Company
InventorsRalph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
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Abstract
Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.
Claims12
A method of treating a warm blooded animal afflicted with tumor cells sensitive to a compound of the formula:
- ##STR7## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR8## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR9## or L and L' taken together is ascorbic acid and x is selected from the group consisting of halogen and hydroxy;
- which comprises parenterally administering to said animal an oncolytic amount of said compound of the above formula.
The method according to claim wherein the compound is [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][pentanedioato(2-)-O.sup.1, O.sup.5 ]platinum.
Dependencies are inferred from the claim text.