US 4,900,754 A · HMG-COA reductase inhibitors

Abstract

Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

Claims29

Dependent claims

A compound of the formula ##STR10## wherein Y is:

--CHR--,
--CHRCHR--,
--CHRCHRCHR--, or
--RC.dbd.CR--;
X, X.sub.1 and X.sub.2 are independently:
R,
NO.sub.2,
NH(CO)R,
N(R).sub.2,
S(O).sub.m R,
F,
Cl, or
Br;
R.sub.1 is:
OR;
R.sub.2 is:
R;
R.sub.3 and R.sub.4 are independently:
H or lower alkyl;
R is:
H or lower alkyl;
n is:
- 2;
and
m is:
0-2i

23 more elements

Dependencies are inferred from the claim text.

Facts

Application

07/328,836Filed 27 Mar 1989 · continuation in part

Priority

21 Dec 1987

Granted

13 Feb 1990

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07D 309/30
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07C 59/54
Containing hydroxy or O-metal groups: containing six-membered aromatic rings and other rings
C07C 59/56
Containing hydroxy or O-metal groups: containing halogen
C07C 59/64
Containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] groups:…

HMG-COA reductase inhibitors

Life of this patent

Abstract

Claims29

HMG-COA reductase inhibitors

Life of this patent

Abstract

Claims29