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US 4,900,748 AGranted
Carbamates related to (-)-physostigmine as cholinergic agents
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsArnold Brossi, Qian-Sheng Yu, John R. Atack, Stanley I. Rapoport
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Abstract
Highly potent analogs of (-)-physostigmine are provided which are potent inhibitors of acetylcholinesterase and butyrylcholinesterase. These compounds are useful in treatment of glaucoma, Alzheimer's disease, myasthenia gravis, and organophosphate poisoning.
Claims13
A compound of the formula:
- ##STR4## wherein R.sup.1 =H, R.sub.2 =CH.sub.3 ;
- R.sup.1 =H, R.sup.2 =CH.sub.3 ;
- R.sup.1 =Bn, R.sup.2 =CH.sub.3 ;
- R.sup.1 =Bn, R.sup.2 =OH;
- R.sup.1 =Bn, R.sup.2 =OCONH--CH.sub.3 ;
- R.sup.1 =H, R.sup.2 =CONH--CH.sub.3 ;
- R.sup.1 =CH.sub.2 =CH--CH.sub.2, R.sup.2 =CONHCH.sub.3 ;
- or
- R.sup.1 =CH.sub.2 --CH.sub.2 --Ph, R.sup.2 =CONHCH.sub.3.
6 more elements
Dependencies are inferred from the claim text.