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AssigneeThe Rockefeller University
InventorsHelen Vlassara, Michael Brownlee, Anthony Cerami
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The present invention relates to a method and associated agents for the inhibition and treatment of protein aging in animals by stimulating the bodies of the animals to increase their recognition and affinity for advanced glycosylation end products. Specifically, the method contemplates the administration of certain agents such as advanced glycosylation endproducts, such endproducts as are bound to the carrier, monokines that stimulate phagocytic cells to increase their activity toward advanced glycosylation endproducts, and mixtures of these materials either alone, or in conjunction with other co-stimulatory agents. Numerous diagnostic and therapeutic applications are defined, and pharmaceutical compositions are also contemplated.
A method for averting the adverse sequelae of the accumulation of advanced glycosylation endproducts in the body of an animal, comprising introducing into said body an effective amount of an agent capable of causing said body to increase its activity of recognizing and removing macromolecules that have undergone advanced glycosylation selected from the group consisting of an advanced glycosylation endproduct, an advanced glycosylation endproduct bound to a carrier, the fluorescent chromophore 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole bound to a carrier, a monokine that stimulates the phagocytic cells in said body to increase said recognizing and removing activity toward said macromolecules, and mixtures thereof.
A method for averting the adverse sequelae of the accumulation of advanced glycosylation endproducts in the body of an animal, comprising:
Dependencies are inferred from the claim text.