Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents
AssigneeG. D. Searle & Co.
InventorsGunnar J. Hanson, John S. Baran
Life of this patent
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Abstract
Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.
Claims4
O-[N-methyl-N-(2 -methoxyethyl)aminocarbonyl]-3-L-phenyllactyl-L-histidineamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof.
O-[N-methyl-N-(2-ethoxylethyl)aminocarb onyl]-3-L-phenyllactyl-L-histidineamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof.
A pharmaceutical composition comprising a therapeutically-effective amount of a renin-inhibiting compound and a pharmaceutically-acceptable carrier or diluent, said renin-inhibiting compound selected from the group consisting of
- O-[N-methyl-N-(2-methoxyethyl)aminocarbonyl]-3-L-phenyllactyl-L-histidineam ide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof;
- and
- O-[N-methyl-N-(2-ethoxyethyl)aminocarbonyl]-3-L-phenyllactyl-L-histidineami de of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof.
A therapeutic method for treating hypertension, said method comprising administering to a hypertensive patient, or to a patient susceptible to hypertension, a therapeutically-effective amount of a compound selected from the group consisting of
- O-[N-methyl-N-(2-methoxyethyl)aminocarbonyl]-3-L-phenyllactyl-L-histidineam ide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof;
- and
- O-[N-methyl-N-(2-ethoxyethyl)aminocarbonyl]-3-L-phenyllactyl-L-histidineami de of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.