Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
AssigneeG. D. Searle & Co.
InventorsGunnar J. Hanson, John S. Baran
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Abstract
Non-peptidyl compounds characterized generally as poly(aminoalkyl)aminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension.
Claims3
O-{N-[2-{N-[2-(N ,N-dimethylamino)ethyl]-N-methylamino}-ethyl]-N-methylaminocarbonyl}-3L-phe nyllactyl-L-histidineamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof.
A pharmaceutical composition comprising a therapeutically-effective amount of a renin-inhibiting compound and a pharmaceutically-acceptable carrier or diluent, wherein said renin-inhibiting compound is
- O-{N-[2-{N-[2-(N,N-dimethylamino)ethyl]-N-methylamino}-ethyl]-N-methylamino carbonyl}-3-L-phenyllactyl-L-histidineamide of (2S,3R,4s)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof.
A therapeutic method for treating hypertension, said method comprising administering to a hypertensive patient, or to a patient susceptible to hypertension, a therapeutically-effective amount of the compound
- O-{N-[2-{N-[2-(N,N-dimethylamino)ethyl]-N-methylamino}-ethyl]-N-methylamino carbonyl}-3-L-phenyllactyl-L-histidineamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.