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US 4,900,744 AGranted
Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles
AssigneeE. I. Du Pont de Nemours and Company
InventorsJeffrey T. Billheimer, Peter J. Gillies, Wendell W. Wilkerson
Life of this patent
Estimating the term…
Abstract
Antihypercholesterolemic thioimidazoles of the formula ##STR1## or a pharmaceutical acceptable salt thereof, wherein R.sup.1 and R.sup.2 independently are H, F, Cl, CF.sub.3, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms; A is alkylene of 7-20 carbon atoms or an alkenyl residue thereof with no more than 2 double bonds; R.sup.3 is H, CH.sub.3 or C.sub.2 H.sub.5 ; and n is 0, 1 or 2, are provided, such as 8-(4,5-diphenyl-1H-imidazol-2-ylthio)octanoic acid ethyl ester.
Claims24
A compound of the formula:
- ##STR19## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 independently are H, F, Cl, CF.sub.3, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms;
- A is alkylene of 7-20 carbon atoms or an alkenyl residue thereof with no more than 2 double bonds;
- R.sup.3 is H, CH.sub.3 or C.sub.2 H.sub.5 ;
- and
- n is 0, 1 or 2.
2 more elements
Dependencies are inferred from the claim text.