3-aryl-5-alkylthio-4H-1,2,4-triazoles
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsJohn M. Kane, Francis P. Miller
Life of this patent
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Abstract
This invention relates to derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles, to their pharmacological properties and to their use as muscle relaxants, spasmolytics, anticonvulsants and anxiolytics.
Claims16
A method for treating muscle spasms to a patient in need thereof which comprises administering a therapeutically effective amount of a compound of the formula ##STR7## or a pharmaceutically acceptable salt thereof wherein Ar is phenyl or naphthyl;
- R.sub.1 is C.sub.1-6 alkyl;
- R.sub.2 is hydrogen or C.sub.1-6 alkyl;
- R is C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy, halogeno, or trifluoromethyl and n is zero, 1 or 2, or R.sub.n -(Ar) is methylenedioxyhenyl;
- and each of m and q is zero, 1 or 2.
A method for treating muscle tension to a patient in need thereof which comprises administering a therapeutically effective amount of a compound of the formula ##STR8## or a pharmaceutically acceptable salt thereof wherein Ar is phenyl or naphthyl;
- R.sub.1 is C.sub.1-6 alkyl;
- R.sub.2 is hydrogen or C.sub.1-6 alkyl;
- R is C.sub.1-6 lower alkyl, C.sub.1-6 alkoxy, hydroxy, halogeno, or trifluoromethyl and n is zero, 1 or 2, or R.sub.n -(Ar) is methylenedioxyphenyl;
- and each of m and q is zero, 1 or 2.
Dependencies are inferred from the claim text.