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US 4,900,740 AGranted
N,N'-disubstituted guanidines containing a carboxyl or a tetrazolyl moiety
AssigneeThe NutraSweet Company
InventorsGeorge W. Muller, Eric Walters, Grant DuBois
Life of this patent
Estimating the term…
Abstract
N,N'-disubstituted guanidines containing a tetrazolyl or glycine moiety are provided as high potency sweetening agents.
Claims43
A compound corresponding to the formula, ##STR17## wherein R.sub.1 is an atom of hydrogen or R.sub.1 is a C.sub.1 to C.sub.4 saturated, unsaturated, acyclic, cyclic or mixed hydrocarbyl or modified hydrocarbyl group and wherein, in the modified hydrocarbyl group,
- 1to 2 atoms of carbon may be replaced by 1 to 2 of the same or different heteroatoms selected from the group consisting of N, O, S, Cl, Br and I,
- and 1 to 3 atoms of hydrogen may be replaced by 1 to 3 atoms of fluorine;
- wherein R.sub.2 is a C.sub.1 to C.sub.13 saturated, unsaturated, acyclic, cyclic or mixed hydrocarbyl or modified hydrocarbyl group and wherein, in the modified hydrocarbyl group,
- 1 to 4 atoms of carbon may be replaced by 1 to 4 of the same or different heteroatoms selected from the group consisting of N, O, S, Cl, Br and I,
- and 1 to 5 atoms of hydrogen may be replaced by 1 to 5 atoms of fluorine;
- n is 0, 1, 2, or 3;
- wherein R.sub.1 and R.sub.2 can be fused;
- ##STR18## wherein R.sub.4 is H or C.sub.1 -C.sub.6 alkyl with the proviso that R.sub.4 can only be alkyl on a single carbon atom when n=2 or 3;
- R.sub.5 is H or C.sub.1 -C.sub.6 alkyl;
- and
- tautomers and physiologically acceptable salts thereof.
8 more elements
Dependencies are inferred from the claim text.